SYNTEGON LAUNCHES NEW MLD
ADVANCED FOR RTU SYRINGES
Following the first virtual
presentation at Interphex, Syntegon
is now introducing its new filling
machine for ready-to-use (RTU)
nested syringes to the market.

The MLD Advanced meets
the increasing requirements of
pharmaceutical manufacturers for
high output with 100 percent in-
process control (IPC). “Especially
with high-value medicines, it is
essential that each drop is filled
and weighed optimally,” explains
Markus Burkert, Product Manager
at Syntegon. “That’s why we have
combined the MLD platform, which
was previously used primarily
for cartridges and vials, with our
technologies for syringe filling.”
The automatic bag and tub
openers, well-known from many
syringe lines, use no-touch transfer
to ensure the aseptic transfer
of the syringes into the filling
area. The Pharma Handling Unit
developed by Syntegon denests
the syringes automatically without
glass-to-glass contact and places
the containers into the
pitch adjustment station.

Here, the syringes are
moved into the machine
pitch and then placed in
the clips of the machine
transport. “This unique
clip system is the first
key feature we adopted
for syringe applications from the
cartridge line,” Markus Burkert
explains. “The special circulating
transport system ensures smooth
transportation and is therefore
ideal for RTU syringes, as well as
vials and cartridges.”
The empty syringes are weighed
using 100 percent IPC, before
they are transferred to the filling
station. The subsequent filling and
stoppering process is based on the
proven FXS series for syringes: the
filling needles are mounted on the
Pharma Handling Unit and allow
for flexible redosing if required.

Thanks to IPC, the filling weight is
controlled precisely. “In addition
to minimising product loss, an
important focus is on providing
documented proof about the
weighing of each container. This
gives manufacturers the certainty
that all containers have been
filled correctly,” explains Klaus
Ullherr, Senior Product Manager
at Syntegon.

containers are returned by the
circulating transport system and
gently placed in the nests by the
Pharma Handling Unit. “This way,
we can offer our customers a
seamless process for their pre-
sterilised syringes from a single
source,” says Klaus Ullherr.

Customers benefit from this
innovative combination of proven
technologies in several ways: in
addition to achieving an output
of up to 400 syringes per minute,
they also receive safe and proven
processes. “By using tried and
tested technologies, the machine
is available quickly, and the risk
is significantly reduced,” Markus
Burkert underlines.

The first customer is already
convinced: the first MLD Advanced
will soon be ensuring gentle
processing and filling of RTU
syringes with 100 percent IPC
at a European pharmaceutical
manufacturer. www.syntegon.com
After stopper insertion
via vacuum or vent tube, the